Methods: Forty six adults living with HIV and aged 50 years and older were enrolled in this study. Participants provided demographic and health history information at study entry. Participants completed cognitive testing at study entry and after wearing an actigraph watch for one week. A sleep diary, fatigue survey and daytime sleepiness survey were also completed each day the actigraph watch was worn. After one week participants returned to the clinic and completed the Pittsburgh Sleep Quality Index (PSQI), and depression and fatigue surveys. They then performed cognitive testing using the NIH Toolbox Cognition Battery and the Montreal Cognitive Assessment (MoCA).
Currently, 42 persons have completed this study with patient participation anticipated to end by January 31, 2018. Complete data analysis will be performed at that time.
Results: Preliminary results of study data (n = 28) reveal a statistically significant negative relationship of moderate strength between global sleep and cognitive function (r = -.47, p = .015). In addition the relationships between cognitive function and sleep latency (r = -.43, p = .030), and cognitive function and sleep efficiency (r -.44, p = .025) were also moderate in strength and statistically significant, suggesting that poorer sleep correlated with lower cognitive function. Preliminary results found 86% of study participants had poor sleep (PSQI score >5), and 58% displayed mild cognitive impairment. These results were in older adults whose HIV was well-controlled with antiretroviral therapy. Further analysis will be performed on the complete data set after the final study participants have completed their study visits.
Conclusion/jDiscussion: Preliminary findings provide evidence that poor sleep negatively impacts cognitive function. Mild cognitive impairment decreases a person’s ability to manage their medications, which is vital to successfully managing HIV disease (Frain et al., 2014). Poor medication management can result in a decreased quality of life, limiting the opportunity to age successfully while living with HIV. Since declines in cognitive function negatively impact a person’s ability to manage their medications, routine assessment and treatment of sleep problems has the potential to improve medication adherence, a vital component of successfully managing HIV disease.
Support: This study was supported through a grant funded by Sigma Theta Tau International and the National Gerontological Nurses Association
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