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Sunday, November 1, 2009: 11:00 AM
Learning Objective 1: to judge the consequences of invasive adjuvant treatment on quality of life in patients with pancreatic cancer
Learning Objective 2: to inform patients about quality of life after intra-arterial chemotherapy and radiotherapy for pancreatic cancer
ABSTRACT
Background: Adjuvant therapies in pancreatic and periampullary cancer have been shown to achieve only marginal survival benefit. In a randomized controlled trial, 120 patients with pancreatic or periampullary cancer after surgery received either adjuvant celiac axis infusion and radiotherapy (CAI/RT) or no adjuvant treatment.
Aim of the study:To compare Quality of Life (QoL) in patients receiving intra-arterial chemotherapy and radiotherapy (CAI/RT) after pancreatoduodenectomy with QoL in patients without postoperative adjuvant treatment.
Methods: During and after CAI/RT, QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) every 3 months during the first 24 months after randomisation.
Results: Eighty-six per cent (n=103) of the patients completed one or more questionnaires, 51 in the treatment arm and 52 in the observation arm. In total, 355 questionnaires were completed. CAI/RT did not impair physical, emotional or social functioning. During and after CAI/ RT, patients had significantly less pain (p=0.02; mean difference 9.7 points) and significantly less nausea and vomiting (p=0.01; mean difference 5.9 points). Overall QoL (global functioning) tended to be better (p=0.08; mean difference 6.5 points) after CAI/RT.
Conclusion: CAI/RT did not impair QoL after pancreatoduodenectomy for pancreatic or periampullary tumours and was even improved during the second half of the follow-up.
Background: Adjuvant therapies in pancreatic and periampullary cancer have been shown to achieve only marginal survival benefit. In a randomized controlled trial, 120 patients with pancreatic or periampullary cancer after surgery received either adjuvant celiac axis infusion and radiotherapy (CAI/RT) or no adjuvant treatment.
Aim of the study:To compare Quality of Life (QoL) in patients receiving intra-arterial chemotherapy and radiotherapy (CAI/RT) after pancreatoduodenectomy with QoL in patients without postoperative adjuvant treatment.
Methods: During and after CAI/RT, QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) every 3 months during the first 24 months after randomisation.
Results: Eighty-six per cent (n=103) of the patients completed one or more questionnaires, 51 in the treatment arm and 52 in the observation arm. In total, 355 questionnaires were completed. CAI/RT did not impair physical, emotional or social functioning. During and after CAI/ RT, patients had significantly less pain (p=0.02; mean difference 9.7 points) and significantly less nausea and vomiting (p=0.01; mean difference 5.9 points). Overall QoL (global functioning) tended to be better (p=0.08; mean difference 6.5 points) after CAI/RT.
Conclusion: CAI/RT did not impair QoL after pancreatoduodenectomy for pancreatic or periampullary tumours and was even improved during the second half of the follow-up.
See more of: Cardiac and Cancer Health Promotion
See more of: Oral Paper & Poster: Clinical Sessions
See more of: Oral Paper & Poster: Clinical Sessions