Monday, November 3, 2003: 10:30 AM-11:45 AM

The Patient Factor: Adherence Predicts Outcome across Chronic Disorders

Learning Objective #1: Know the relationships between medication adherence and treatment outcome in a variety of chronic disorders
Learning Objective #2: Know about measurement issues in adherence with regard to impact on clinical outcomes
SYMPOSIUM OVERVIEW: The premise of pharmacologic treatment is that it will improve function, the assumption of treatment is that patients will comply with directions. Physicians often assume that non-responders are taking the wrong medication, or that the dose is not strong enough, without considering or questioning their patients as to dose and inter-dose medicating. Nurses, who are more directly involved in adherence monitoring, generally rely on patient reports or pill counts. Research has addressed the problem of poor adherence for the past 4 decades. Much of the research has focused on the prevalence and predictors of adherence, research methodologies, and the development of measures of adherence. Depending on methodology, 20-80% of patients fail to take medication as prescribed for a variety of illnesses; electronic event monitoring has been proven to be a more accurate measure of medication adherence than self-report or pill counts. Despite the prevalence of noncompliance, and the clear conceptual link between disease management and medication adherence, few studies have carefully examined the ways in which adherence affects outcome. This symposium will focus on adherence and outcome among patients with different chronic disorders. Each of the studies employed electronic event monitoring (EEM) to measure medication adherence, and each of the researchers report significant impact of medication adherence on outcome. Dunbar-Jacob et. al. examines the relationship between change in adherence over six months and change in clinical outcome in patients with RA. Erlen et. al. examines the relationships between adherence to antiretroviral therapy and health related quality of life and clinical response. Schlenk et. al. report on a study to determine if there was a relationship between adherence and blood pressure (BP) controlling for selected demographics. Sereika & Dunbar-Jacob focus on the hypothesized interrelationships between treatment, adherence and outcome in clinical research, and on factors impacting the adherence-outcome relationship.
Organizer:Carol Stilley, PhD, RN
 Adherence, Quality of Life, and Clinical Response in Persons with HIV Infection
Judith A. Erlen, RN, PhD, FAAN, Susan Sereika, PhD, Mary Pat Mellors, RN, PhD, Jacqueline Dunbar-Jacob, RN, PhD, Susan Hunt, MD, Christopher M. Ryan, PhD, John Mellors, MD
 Relationship Between Adherence to Antihypertensive Medication and Blood Pressure
Elizabeth A. Schlenk, PhD, RN, Mildred Jones, PhD, RN, Julius Kitutu, PhD, Susan Sereika, PhD, Willa Doswell, PhD, RN, FAAN, Jacqueline Dunbar-Jacob, PhD, RN, FAAN
 Relationship Between Changes in Adherence to Pharmacotherapy and Clinical Outcomes in RA
Jacqueline Dunbar-Jacob, RN, PhD, Mary Chester Wasko, MD, Elizabeth A. Schlenk, PhD, RN, Joan Rogers, PhD, Susan Sereika, PhD
 The Relationships between Treatment, Adherence Behavior and Clinical Outcome: Does Adherence Mediate the Treatment Response?
Susan Sereika, PhD, Jacqueline Dunbar-Jacob, RN, PhD

37th Biennial Convention - Scientific Session
Sigma Theta Tau International