Learning Objective 1: 1. Evaluate sleep disturbance, fatigue and motivational disturbance in patients with pituitary tumors.
Learning Objective 2: 2.Describe the relationship between factors associated with sleep disturbance, fatigue and motivational disturbance in patients with pituitary tumors.
Purpose: To determine patient perception and severity of sleep disturbance and fatigue and if these correlate to perceived motivational disturbance, tumor size and pituitary hormonal dysfunction in patients with pituitary tumors.
Methods: A total of sixty seven subjects ( 47F/20M) with pituitary tumors meeting criteria were asked to complete a 17 item questionnaire identifying and quantifying sleep disturbance, fatigue and motivational deficiencies on a 6 point Likert scale (no dysfunction to severe dysfunction). On average a moderate level of dysfunction was reported in each category.
Results: All dysfunctions were significantly correlated (p>.000). There was no significant gender difference in the perception of sleep and motivation dysfunction but females perceived more fatigue than males t(64) = 2.49 ( p=0.015). A significant correlation was found between sleep disturbance and multiple pituitary hormonal deficiencies (rs=.27, p= 0.027) and greater sleep disturbance correlated with patients with smaller tumors rs=.256, p=0.037.
Conclusion: Patients with small pituitary tumors (<1cm), without pituitary deficiencies, require evaluation and treatment for sleep disturbance with a particular focus on fatigue in women. Further understanding of the etiology of these dysfunctions is needed in order to develop appropriate therapies.