Menopausal Dyspareunia and Probiotics: A Future Approach?

Purpose: A pilot study was conducted for the inquiry of vaginal probiotics for menopausal women with self-reported dyspareunia.

Methods: Initial menopausal survey tool for assessment of urinary incontinence, dyspareunia and general vasomotor complaints allowed for women with self-reported dyspareunia to be further evaluated. potential candidates where then contacted and offered the opportunity to participate in an open lable study using a vaginal probiotic once per week for 6 weeks. After full disclosure and IRB approved consent was signed, the subjects examined and vaginal ph measurement obtained. The Female Sexual Function Index (FSFI, 2002) was administered. After 6 weeks of intervention, the women returned, repeated the FSFI and were examined with vaginal ph reassesed. A diary of dates and times probiotic was used and sexual intercourse took place was kept during the study and turned in to the PI.

Results: 107 menopausal women were screened, 37 fit the criteria of self-reported dyspareunia. 10 entered the enrollment process, only 7 completed. 2 discontinued the study due to out of state travel and 1 due to partners sudden illness. FSFI scores showed improvements in all 6 domains, including a decrease in pain and vaginal dryness.  

Conclusion: The initial data suggests larger enrollment and data collection will be necessary. Further research into the vaginal microbiome and its role in vaginal function is needed.