Description/Overview: Today’s healthcare environment is increasingly complex and ever changing. Evidence-based practice (EBP) has been identified as a critical requirement to achieve the Triple Aim in healthcare. Although it is well established that evidence-based practice (EBP) improves healthcare quality and patient outcomes as well as reduces morbidities, mortality, medical errors, and costs, it is not standard practice by the majority of health professionals. It is essential for healthcare organizations to transform their institutions to evidence-based enterprises by deeply integrating EBP into their day to day operations, culture, and work environments to effectively meet goals, exceed benchmarks, and provide high quality care to individual patients, families, and the community. Many organizations and leaders are struggling to find effective mechanisms to truly change their cultures and work environments to leverage their internal resources when attempting to shift from a tradition-based care culture to an evidence-based practice culture. Most organizations fail to engage external EBP experts and resources available to inform their journey and enhance their success. This session will present the experiences of a nurse executive and a healthcare enterprise that intentionally and systematically engaged both internal stakeholders and external experts to achieve successful integration of EBP into the organizational culture and work environment. This session will provide insights into the organization’s trajectory where reflective inquiry, organizational assessments, data collection and analysis, along with engagement of an expert collaborative academic partner served as effective tools for developing an innovative and pioneering program of evidence-based practice. The critical importance of the nurse executive/leaders’ knowledge, actions and attitude during the EBP transformation will be highlighted. This example demonstrates how nurse executives/leaders who understand, embrace and role model EBP can significantly influence organizational dynamics and empower others in the journey toward advancing an EBP culture to achieve and sustain improved outcomes.