Description/Overview: A majority of omics-based research studies and clinical application of findings center on the family pedigree, relying on family history to assess heredity and identify health risks across the lifespan. Nurses are increasingly involved in omics research and healthcare from obtaining the family pedigree, ordering genetic tests, interpreting findings, and counseling on diagnosis and follow-up care with patients and families. A major issue involved in assessing heredity of familial disorders is the lack of information available for many underserved and/or minority families who may have been transported or immigrated to another country without much history available regarding previous generations health histories that would include information on chronic diseases, cause and age of death, etc. Because many underserved ethnic minorities in the United States with ancestral origins in other regions such as Africa or Latin America suffer disproportionately from chronic diseases (such as: hypertension, obesity, hyperlipidemia, cardiovascular disease, etc.) addressing these disparities will be the foci of this research symposium. As nurses are at the forefront of patient interactions it is only fitting that nurse scientists lead the charge in addressing health disparities in the quest for precision healthcare. This will entail conducting nurse-led omics research studies that can be translated from the bench-to-bedside and developing leaders who can become agents for change in precision healthcare by integrating omics technologies into research and clinical practice. By utilizing, evaluating and applying the use of advanced omics technologies in the laboratory such as genome-wide, epigenome-wide, metabolomic, proteomic, and/or sequencing techniques, nurses are well situated to broaden the landscape of precision-based healthcare. The presentations in this symposium will address how these methodologies may be used bridge the gap in health disparities and develop health interventions on a global scale. Nurse scientists conducting omics research with ethnic minority families will discuss their findings and provide implications for future research and recommendations for application to clinical practice. We anticipate that results of this symposium may be used as a foundation for an omics tool-kit/workflow for both nurse scientists and clinicians working with diverse populations.