Description/Overview: Cardiovascular disease (CVD) is responsible for the majority of deaths globally. There is a worldwide epidemic of Type 2 diabetes (T2DM), which is not only an important risk factor for the development of CVD, but a prognostic marker for CVD-related morbidity and mortality. In western countries, nursing has had an important role in the prevention and management of these conditions, including the prevention of disease-related complications. While the prevalence of CVD and T2DM are increasing in Africa and projected to rise further, there are multiple challenges to prevention and management. Many countries in Africa face the “double-burden of disease” having to confront the challenges of these two chronic diseases, as well as continuing to prevent and manage infectious diseases. Nursing has a unique opportunity to lead efforts in CVD and T2DM prevention, as well as direct disease management, however, adapting nursing interventions to a country’s specific context, including the African worldview, must be accomplished. The purpose of this symposium is to present the state of the knowledge on the prevention and management of CVD and T2DM and develop a plan for adaption to African countries, taking into account the unique needs within Africa. The research evidence will be synthesized and presented in order to provide a basis for nursing interventions and future research aimed at reducing the risk of CVD and T2DM and their complications. Strategies for implementation in African countries, from the perspective of urbanization, which contributes to a sedentary lifestyle and malnutrition (obesity and undernutrition), along with other contributing factors, will be discussed. The session will also provide an opportunity for discussion by audience members on clinical and research strategies to address the global burden of both cardiovascular disease and type 2 diabetes in Africa. Audience participation will provide insight into country-specific implementation strategies and suggestions for nursing research.