Methods: Quasi-experimental design with repeated measurements and two different groups: the experimental group will participle in a psychoeducational program which consist in 12 sessions of two hours per session in which will develop abilities for the solution of problems for care and self-care in the informal caregivers participants; the control group will receive conferences about chronic illness and healthy life style. The central hypothesis in this project is that the informal caregivers participants in the experimental group will reduce significantly his level of stress, anxiety and depression in comparison to the participants of a control group, rated through the use of biomarkers.
The sample size will be calculated using ANOVA for repeated measurements with three levels (level of trustfulness 95%, potency =0.90) for the interaction time per group, and a size of the large effect. We will use the nQuery Advisor 7.0 software. The variables result that will be measured before, during, after and folow-up about the experimental condition through validated instruments will be associated to the profiles of genetic expression in cortisol levels in saliva and serotonin in blood. Additionally will be identify the presence of polymorphism associated at this study variables. The data will be processed on the SPSS V24 database. The study will be through the semester August - September 2017.
Results: The variables result will be analyzed using ANOVA of repeated measurements and the post-hoc analysis to determine the differences between the groups and the effect size.
Conclusion: Will be discussed the use of biomarkers in the evaluation about the effect of the interventions in nursing in relations with the health condition that affect the quality of life of the mexican informal caregivers of older adults with dementia. In addition how nursing could be benefit with the use of biomarkers like an objective tool that promote the information about the mechanism that could promote the emotional health in informal caregivers.