This process involved widespread consultation with nurses in practice settings and interdisciplinary colleagues in medicine, business, design, and engineering. We also received great advice and support from the School’s Board of Overseers. From these consultations, we developed areas of focus and identified learning needs of faculty and students and developed a foundation for using innovation as a methodology. Within the university, extensive consultations and engagement led to having seats at many tables regarding campus-wide innovation initiatives. Partnering with health system based centers for innovation provided opportunities for select faculty, students, and clinicians to be engaged in designing, implementing, and evaluating new innovations to improve patient care and outcomes. Key to this experience was adding design thinking in the health care environment to core knowledge. Consultation with businesses resulted in select projects in which nurse researchers were involved in the design and evaluation of specific innovation projects. We also invested resources to support our strategic direction, including an innovation specialist and consultant, to support faculty and student engagement in innovation efforts. Results to date include the formation of several start-up companies formed by nurse researchers, the development of a course to integrate innovations in nursing, and involvement of students, faculty, and clinicians in innovation efforts within the health system and on campus. Further, we recognize the importance of building a culture of innovation not only within the school but within the discipline of nursing. Based on our experiences, we offer several recommendations: 1) recognize and articulate nurses a innovators; 2) engage in discussions with a broad network to build relationships and identify opportunities in innovation; and 3) set a vision for how you will operationalize innovation in research, practice, and teaching given your context