Paper
Thursday, July 22, 2004
9:30 AM - 10:00 AM
Thursday, July 22, 2004
2:30 PM - 3:00 PM
Genetics of Gestational Diabetes: A Case Control Association Study
Kathleen Utter King, CNM, MS1, Kathleen B. King, RN, PhD, FAAN1, Jeanne Grace, PhD1, and Chin-To Fong, MD2. (1) SON, University of Rochester, Rochester, NY, USA, (2) Pediatrics, University of Rochester, Rochester, NY, USA
| Learning Objective #1: n/a |
| Learning Objective #2: n/a |
Purpose: The primary aim is to identify the allelic frequencies of genetic allelic variants in individuals with current or previous GDM. Hypotheses: The frequency of T2DM-implicated genetic alleles will be higher in women with GDM than in controls. Background and Significance: GDM is first diagnosed during pregnancy and occurs in 7-14% of all pregnancies. Many women with GDM later develop T2DM. Diabetes is a major risk for heart disease. Women with diabetes are 3-7 times more likely to die of CHD than women without diabetes; men with diabetes have a 2- to 3- fold increased risk of death from CHD as compared to men without diabetes. The reason is not yet completely understood; however, there is some suggestion that diabetes reduces or negates the protective effects of the female hormone estrogen. Twin and family studies demonstrate that T2DM is heritable. Certain genetic alleles are implicated in T2DM; it is not yet known whether these alleles are also associated with GDM. Design: Case-control association study. Sample: 171 with and 171 without GDM, matched for race/ethnicity, age @ index pregnancy and BMI. Variables: Candidate genetic alleles implicated in T2DM: PPAR gamma, Beta-3-Adrenergic Receptor, GRL, Calpain 10. Matching Control Variables: Ethnicity/race, age (+/- 2 years) and pre-pregnancy BMI ± 2 kg/m2. Statistical Analysis: Proportions of alleles will be compared by chi square analysis. Odds ratios and 95% Confidence Intervals adjusted for BMI will be calculated by logistic regression analysis. Differences in clinical characteristics between subjects with and without the variants will be evaluated using a 2-tailed test. Implications for Practice: Because interventions have been shown to be beneficial in preventing and delaying the onset of T2DM, early knowledge of genetic factors which predispose women to GDM & T2DM could lead to earlier interventions that would further improve the health of women.
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Sigma Theta Tau International
July 22-24, 2004