Abstract Objective: SARS was a global infectious disease in 2003. Some nurses had multiple roles to work around workplace and family to deal with patients and children. The purpose of this study was to explore the stressors, and coping strategies of a group of employed, Taiwanese women as mothers and nurses in their maternal and career roles during SARS epidemic. Method: Six focus groups with Taiwanese clinical nurses as mothers were recruited from two large medical centers in Taiwan. There were 6-8 participants in each group. The total participants included 42 nurses who had children as mothers. A semi-structured interview guide with open-ended questions was used during the 90-min focus group discussion. Audio-taped focus group discussions were permitted by all of the participants and transcribed verbatim for qualitative data analysis. Constant comparative method was used to analyze the typed transcripts. The emerged themes were generated to portray the perception of stress of employed Taiwanese women as mothers and nurses. Findings: These employed mothers in medical centers, experienced many stressful aspects of functioning in multiple roles during SARS epidemic in Taiwan, including uncertainty of being infected, stigma from community, being isolated, and role overload. Moreover, these women coped stresses by social and spouses' supports, and utilizing colleague and family resources. Conclusion & Implications: The findings from this study will assist health care providers to understand the stresses that nurses had multiple roles during the hazards of infection disease outbreak. It is also essential for them to develop more effective interventions for supporting and empowerment as nurses who have children in maternal and career roles. The results of this study could promote occupational nursing care for nurses.