As Indigenous knowledge system continue to emerge, as a discipline there is still a lot of debate concerning the research methodologies to be used in the field.  In this study grounded theory was used based on the theory of symbolic interaction. The method was chosen as it seeks to explain and understand how individuals define their reality and how they act in relation to their beliefs and realities.  The constant comparative analytical strategy was used incorporating three levels of coding as described by Strauss & Corbin (1990). As data analysis and the coding process continue, categories started to emerge, and as it is the case with grounded theory, the dirt theory also emerged. The concept “dirt” (uncleanliness) is viewed as the main cause of sexually transmitted infections(STIs).  The understanding of “dirt” is placed in the context of uncleanliness in the form of discharges such as menstruation, post abortion discharges and lochia (post partum discharges).  Women are viewed as repositories of STIs.  Methods of destigmatising the diseases and making the community aware of gender discrimination surrounding STIs were recommended. This paper aims to guide the reader through the methodology used and the various steps that the researcher followed in developing the theory surrounding Sexually Transmitted Diseases as viewed by the Vhavenda. .