Purpose: The purpose of this pilot study was to categorize types of sleep problems in patients who have experienced renal transplantation, test recruitment procedures for a larger study, determine feasibility of questionnaires and actigraphy monitors, and gather preliminary data regarding valid and reliable measures for sleep disturbance and fatigue.
Design and Methods: A pilot study was conducted with the screening of 10 participants from a renal transplant clinic in a western U.S. state. Four participants met the criteria for a sleep disturbance and continued the study. In addition to actigraphy monitoring as a measure of sleep, biomarkers included hemoglobin for anemia and hemoglobin A1C as an indicator of glucose metabolism related to fatigue level along with relevant personal and treatment variables.
Results: Four of the 10 participants had sleep disturbance and continued in the study. Even though there were only 4 participants, self-report of sleep quality correlated with actigraphy in all 4 participants. The better the self-report, the better the sleep efficiency and the more minutes of sleep. The lab values (Creatinine/BUN/Hgb/Hct) and the sleep variables (fatigue, sleep quality, sleep efficiency) revealed that the better the sleep and the more minutes of sleep, the lower the creatinine and BUN.
Conclusions: The pilot study aims were achieved and the plan to do a larger study is appropriate. Sleep disturbance and fatigue has not been fully studied in renal transplant patients and further study is needed - in this population - for best and appropriate interventions.
See more of: Oral Paper & Poster: Science Sessions