Description/Overview: Background: Because of the importance for advancing the science of health, NINRs Strategic Plan includes self and symptom management and health and health promotion and disease prevention as key behaviors to improving quality of life. Nowhere are these areas more impactful on the health of the population than are the diseases or conditions that require the person to control and/or manage their health conditions over a length of period. Purpose: The purpose of this symposium is to present three papers that focus on the review, testing, and evaluation of the use of technology in enhancing self and symptom management. Methods: We will present two systematic reviews and one feasibility study focused on a chronic health condition and to promote healthy life styles and to prevent chronic illness. The conditions include fibromyalgia syndrome and hypertension or overweight and obesity. The review included technology used for web based interventions via a smart phone, computer, and an interactive, computed-based program with educational modules. Outcomes include participant knowledge, self-management, quality of life, symptoms in one review; the second looked at symptom severity, activity, function, and satisfaction; and the third focused on anthropometric measurements. Results: Results of one review indicated an increase in knowledge, pain, depression and fatigue reduction and a decrease in sleep difficulties over time. The feasibility study found significant changes in symptom severity, activity and function and mixed results in preference over technology versus health care provider contact. The third review paper found significant reductions in waist circumferences and a reduction in BMI. Conclusions/Implications: These outcomes suggest web-based interventions can be effective in delivery of education and support, can be incorporated as helpful in routine care, but should incorporate social support, feedback, and counseling. Use of technology can be transformative and useful in remote communities but continue to include patient involvement and the health care provider.