Purpose: Objectives in this study was to investigate the level of anxiety and depression according to the stages of autologous and allogeneic hemopoietic stem cell transplantation(HSCT). It would be provide the basic data of effective psycho-emotional nursing intervention.

Methods: We reported on 52 patients, including 19 with autologous HSCT, and 33 with allogeneic HSCT from August 2002 to August 2003, at a university hospital. Spielberger's State-Trait Anxiety Inventory and Jung's Depression Inventory were used to measure levels of anxiety and depression, respectively, at admission time, the day before HSCT, and discharge time. Data was analyzed using SAS program that included Chi-square test, Fisher's exact test, repeated measures ANOVA and Stepwise multiple regression analysis.

Results:  In all stages of HSCT, the level of anxiety of patients who underwent allogeneic HSCT was significantly higher than that of autologous HSCT(p=0.047). The depression at the day before before HSCT was significantly higher than that at admission time. The major variable affected anxiety in autologous HSCT was depression. Specially depression and gender were significant predictors to explain anxiety in allogeneic HSCT at admission time(61%). Experience of relapse and gender were significant predictors to explain anxiety in allogeneic HSCT at discharge time(36%).

Conclusion: We recommend that the anxiety and depression be intentionally researched during the stages of allogeneic HSCT, specifically in the day before HSCT. It is necessary to develop an effective psycho-emotional nursing intervention according to the stages of HSCT.