Learning Objective #1: Listeners will understand practical guidelines for providing care of premature labor pain women.

Learning Objective #2: Listeners can understand updated knowledge about premature labor pain care based on research.

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This article shows developing clinical nursing practice guidelines (CNPG) in pregnant women, using  tocolytic agents to inhibit the preterm labor. The CNPG is composed of information, analyzing, and synthesizing researches involved. All nursing guidelines were organized. The contents and language were validated by gynecological and midwifery experts. The contents and language, the  guidelines then were tested with 12 pregnant women with the average age of 29 years(age from 21 to 41 years) admitted to the labor room at Ramathibodi Hospital from August1 to October31,2005.These pregnant women had labor pain with premature labor. The mean of the gestational age was 30 weeks (between 27 and 33 weeks). Among these, 10 cases received the tocolytic agent — bricanyl or terbutaline  sulfate. The others received magnesium sulfate, adalat (nifedipine). The results showed there were no complications from uses of  tocolytic agents. Tocolytic agents were able to inhibit premature labor in 10 out of 12 pregnant women (83 % ) and  these women were able to give birth at GA  37 weeks or over. Among these 10 pregnant women who used  tocolytic drugs, eight of them received bricanyl and the rest of them received magnesium sulfate and adalat. Tocolytic agents could not help two participants to inhibit premature labor due to having other complications. One of  these two participants (gestational age of 32 weeks) needed an operation of caesarean section due to antepartum haemorrhage from  placenta previa totalis and the other (gestational age of 27 weeks) had  a  normal labor delivery due to antepartum  haemorrhage from low lying placenta. In conclusion, delveloping CNPG with evidence-based practice is helpful in the clinical setting in terms of  preventing pregnant women from complications of applying tocolytic agents and assisting pregnant women with using them in inhibiting premature labor.