Effectiveness of Oral Antidiabetic Drugs Combined with Other Medications in Type 2 Diabetic Persons Without Insulin Treatment

Jimenez-Garza, Octavio A.

Wednesday, July 13, 2011: 10:30 AM

Octavio A. Jimenez-Garza, MS, RN
Nursing and Obstetrics, Universidad de Guanajuato Campus Leon, Leon GTO, Mexico
Edith Reyna- Echeveste
Departamento de Enfermeria y Obstetricia Sede Leon, Universidad de Guanajuato, Leon, Mexico
Luxana Reynaga-Ornelas, MN, RN
Departamento de Enfermería y Obstetricia sede León, Universidad de Guanajuato Campus León, Division de Ciencias de la Salud, Leon. Guanajuato, Mexico
Adriana Dávalos-Pérez, MS, RN
Bulevard Puente del Milenio 1001. Fracción Predio San Carlos, Universidad de Guanajuato Campus León. División de Ciencias de la Salud, León, Guanajuato, Mexico

Learning Objective 1: identify possible effects of combining oral antidiabetic drugs with another medications on glycemic control in a sample of mexican diabetic patients not treated with insuline

Learning Objective 2: make conclussions about the outcome derived from drug-drug interactions in diabetes pharmacotherapy

Purpose: To compare glycemic control evolution during one year period in type 2 diabetic patients consuming only oral antidiabetics vs. type 2 diabetic patients whom consumed another medications (not insulin) besides oral antiabetics.

Methods: Data were collected from 241 medical records of Mexican type 2 diabetic patients attending at a public health institution during one year, whom were not treated with insulin for glycemic control. Cases were subdivided in four groups according to teatments of one or two oral antidiabetics and one or two antidiabetics plus another medications (4 groups). Taking 5 values of fasting blood glucose as the outcome measure, we compared differences between groups using repeated measures ANOVA.

Results: Mean age of the sample was 57.5 + 11.5 years. Years of have been diagnosed as diabetic were 7.7 + 3.2. Results obtained from statistical analysis crossing different variables are summarized in the next chart:

Dependent Variable

Independent Variable

Result

a) Fasting blood Glucose (5 measures)
b) Fasting blood Glucose (5 measures)
c) Fasting blood Glucose (5 measures)

Group of treatment
Group of treatment. Covariate: Years of have been diagnosed as diabetic
Years of have been diagnosed as diabetic (divided in 4 groups)

No statistically significant
Statistically significant (p= 0.001)
No statistically significant, but with a noticeable trend when comparing the group of 1 to 4 years of being diagnosed compared with the group of 15 a 20 years.

Conclusion:

Analyzing fasting blood glucose, which was the way of assessing glycemic control in these patients, there were no differences as far as taking one or two antidiabetics, neither when antidiabetics were consumed along with antihypertensive and antibiotics in spite of these latter classes of drugs have been reported to affect the prognosis of type 2 diabetic persons, attributed to drug-drug interactions when combined with oral antidiabetics.

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