This presentation will discuss the various technical issues and standards related to the implementation of a clinical information system and electronic reference materials on handheld devices in an academic environment. Three major areas will be addressed including computing environment and infrastructure, technical standards and compatibility, and support infrastructure. Computing environment and infrastructure will identify the physical setup of technology used in this program. Technical standards and compatibility will address the hardware and software standards, how the different devices interact with one another, and how technology trends effect vendor and equipment choice. Finally, support infrastructure will speak to the importance of having clearly defined support roles, what those roles are, common issues encountered and their solutions and how adequate training of instructors and IT support staff is an integral part in achieving success with new technology.