Description/Overview: Catheter-associated urinary tract infection (CAUTI) is a predominately preventable hospital-acquired infection which on average costs hospitals $896 per infection (Zimlichman et al., 2013). CAUTI prevention is highly dependent on changing nursing culture and sustaining practice change. Key concepts sited by Melnyk and Fineout-Overholt in the Evidence-Based Advancing Research and Clinical Practice Through Close Collaboration (ARCC) Model include assessing the organization’s readiness for change and clinicians’ beliefs about the value of the practice change. In addition, the Lean Six Sigma concepts of DMAIC (Define-Measure-Analyze-Improve-Control) and the Institute for Healthcare Improvement’s PDSA (Plan-Do-Study-Act) cycle supplement the ARCC model, highlighting methods to sustain and evaluate effects of change. Integration of all three models using a team-based approach is essential when introducing methodical practice change. This symposium presentation will address how a regional acute care hospital implemented and sustained evidence-based practice changes to reduce CAUTI. The symposium will guide clinicians through the EBP process and give clinicians the tools to improve outcomes using best evidence. In particular, identification and continued clinical validation of process measures and their relationship to outcome measure achievement will be discussed. In addition to sharing experience with integrating the ARCC, DMAIC, and PDSA models to implement EBP changes, the team will share lessons learned and continued clinical inquiry questions which are a direct result of practice change.