Background: Daughter caregivers tend to score worse on physical or mental well-being measures than males and wife caregivers. Gaps are left unbridged in understanding implications relevant to the caregiving experiences of daughter caregivers, the largest proportion of involving caregivers in Asian. Purpose: The purpose of this critical review is to use meta-analysis review technique to investigate the variables associated with negative self-appraisals of daughters as family caregivers of elders above 65 years old and over. Methods: Using Fisher's r-to-z transformation to normalize the distribution among five included studies and construct a level 95% confidence interval for the population value. Results: CG's physical health (r= -.31, t= -4.24, p< .001) and mastery (r= -.41, t= -4.38, p< .001) were moderately negatively related to CG's depression. Discussion and Future Research: Implementation of this result requires more longitudinal and experimental study designs. The payoff is in terms of better understanding of the effectiveness of caregiver's health promotion and caregiving self-efficacy on the relief of the depression of daughters and similarly, wife caregivers need to enhance caregiver's understanding of the disease and also involves instructing them about the progress of the disease, linking the understanding to strategies in their caregiving experience . Unlike daughter caregivers, male caregivers are more likely to need the information about resources and services; meanwhile they may experience guilt and embarrassed when needing to ask for assistance. All efforts are in vain if we cannot provide the services that are needed. Researchers and programmers have to recognize the significance of gender- and kinship- sensitive public health resources programs in order to meet the specific needs among diverse of family caregivers.