Purpose: This study was conducted to investigate the effects of foot reflexzone massage on state-anxiety and discomfort of ovarian cancer patients receiving chemotherapy. Method: A quasi experimental design with a non equivalent control group and non synchronized design was used. The subjects consisted of 40 patients admitted to C University Hospital. Twenty subjects were assigned to the experimental group and received foot reflexzone massage everyday for 3 days. The other 20 subjects were in the control group and received routine care. Foot reflexzone massage was done on both feet of the subjects for 30 minutes for 3 days using standard protocol. The 'State-Anxiety Inventory' developed by Spielberger was used to measure the degree of state-anxiety. Discomfort was assessed using the 'Symptom Distress Scale' of McCorkle and Young. Data was analyzed by a SAS program using t-test, Wilcoxon signed rank sum test and Wilcoxon rank sum test. Results: State-anxiety and discomfort of subjects receiving foot reflexzone massage were significantly lower than those of th e control group. Conclusion: These findings indicate that foot reflexzone massage could be an effective nursing intervention for relieving state-anxiety and discomfort in ovarian cancer patients.