Two interventions with proven effectiveness in improving outcomes for children and parents in high risk families—home visitation by professional nurses and a standardized parent training program--were adapted for the program. In the effort to translate this research into practice, multiple challenges emerged including maintaining fidelity of the intervention and limited dosage of the intervention related to missed visits, language barriers and chaotic family lives. Over a five year period, families (n = 82) received at least one visit. Eligibility criteria included at least two of the following: low income, limited social support, mental illness, chemical dependency, limited education, history of abuse, or involvement with criminal systems. Forty-two percent of families were ethnically diverse with 21% non-English speaking. Data related to family outcomes were gathered over 4 years using standardized assessment tools. Although analysis was difficult due to missing data, trends in positive directions emerged related to reduced parenting stress and depression, and improved child behavior. Using a mixed method design, student data were gathered for five years. Results showed significant gains in knowledge of public health nursing and community resources, increased sensitivity to challenges faced by high risk families, an expanded repertoire of family interventions, and an increase in self-reported confidence working with clients from diverse and disadvantaged backgrounds. Students also learned from their participation in the process of translating research into practice. Strategies and challenges in translating best practices into clinical settings will be discussed.